Cisplatin vs carboplatin ototoxicity

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August undefined, 2024

WebThe antineoplastic agent's cisplatin and carboplatin are widely used as they are highly effective. Unfortunately, ototoxicity is a frequently encountered side effect of platinum-based chemotherapy. Clinically, patients generally develop a progressive, bilateral, and irreversible sensorineural hearing loss. WebSep 20, 2024 · The incidence of hearing loss was lower in the sodium thiosulfate and cisplatin arm (39%) compared with the cisplatin alone arm (68%); unadjusted relative risk 0.58 (95% CI: 0.40, 0.83).

The side effects of platinum-based chemotherapy drugs: a review …

WebChemotherapeutic (antineoplastic) drugs, particularly those containing platinum ( cisplatin and carboplatin ), can cause tinnitus and hearing loss. Hearing loss can be profound and permanent, occurring immediately after the first dose, or can be delayed until several months after completion of treatment. WebCis-diamminedichloroplatinum (cisplatin), a divalent platinum compound and cell-cycle nonspecific chemotherapeutic agent, produces a permanent high-frequency … ipsen logistics kerix

Ototoxicity of cisplatin vs. platinum analogs CBDCA (JM …

WebCisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. Cisplatin induces ototoxicity, peripheral (most prevalent) and central (rare) neurotoxicity. WebThe platinum-based drugs cisplatin, carboplatin and oxaliplatin are regularly prescribed in the treatment of cancer and while they are effective, their use is limited by their severe, dose-limiting side effects (also referred to as adverse effects/events). In total, a cancer patient can experience any combination of around 40 specific side effects. WebMar 29, 2024 · Platinum-based agents are a standard chemotherapy treatment for malignancies in both pediatric and adult populations. 1 However, mitigating and managing chemotherapy-associated adverse events remains a concern. 2 Ototoxicity is a well-documented side effect of these platinum-based agents, especially cisplatin. This … ipsen layoffs

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Relationship Between Cisplatin Administration and the …

WebJul 3, 2024 · Cisplatin is a widely used chemotherapeutic agent with a high degree of ototoxicity and an average incidence of over 60% ( Karasawa and Steyger, 2015 ). Ototoxicity depends on several factors, including patient age, cumulative dose of cisplatin, and genetic susceptibility ( Landier, 2016; Lanvers-Kaminsky and Ciarimboli, 2024 ). WebMar 25, 2024 · The aim of this study is to evaluate the current state of ototoxicity monitoring for patients receiving cisplatin chemotherapy in an academic medical center with particular attention to how closely monitoring adheres to national ototoxicity guidelines. Case series including retrospective medical records review of patients (age > 18) treated … ipsen incorporatedWebCarboplatin. Cisplatin. Loop diuretics (water pills) Loop diuretics help your kidneys move excess salt and fluid out of your body. Ototoxic types include: Bumetanide. Ethacrynic acid. Furosemide. Torsemide. Other ototoxic drugs and chemicals Rarer causes of ototoxicity include: Quinine: Drugs providers use to treat malaria. ipsen innovation for patient care

"WebAug 19, 2007 · Pooling the results of all of these cis vs. carbo studies together, the response rate with cisplatin combinations was higher (30% vs. 24%), and the overall survival … " - Cisplatin vs carboplatin ototoxicity

Cisplatin vs carboplatin ototoxicity

Special Issue "Metal-Based Complexes in Cancer Treatment"

WebSep 21, 2016 · Cisplatin is the most ototoxic drug known, and a mean ototoxicity incidence of 33% has been reported when patients received a single dose of 50 mg/m 2 … WebCisplatin has dramatically improved the survival rate of cancer patients, but it has also increased the prevalence of hearing and neurological deficits in this population. …

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WebOct 8, 2010 · Carboplatin, a therapeutic alternative to cisplatin, has been shown to be less ototoxic, with reported toxicity rates of 0–38% [ 4, 10 – 12, 18, 19 ]. Carboplatin is also … WebNational Center for Biotechnology Information

WebBesides myelosuppression, nephrotoxicity and ototoxicity are dose-limiting for cisplatin, whereas thrombocytopenia is dose-limiting for carboplatin. Cisplatin is extensively bound to plasma proteins and clear pharmacokinetic-PD correlations have been identified for the ultrafiltrable, i.e., unbound fraction of the drug in plasma and toxicity as ... WebFeb 11, 2024 · Cisplatin is a highly effective chemotherapeutic drug used against a wide range of childhood and adult cancers, but cisplatin crosses into the cochlea, which often results in permanent sensorineural cisplatin-induced hearing loss (CIHL).

Web18/40 (45%) evidence of ototoxicity at audiometry. To date we have seen no neuro- or ototoxicity with carboplatin and 1/40 (2.5%) have developed WHO grade I renal toxicity. Myelo- ... Key words: Ovarian cancer; cisplatin, carboplatin, toxicity, efficacy, randomized study. Cisplatin is the most active drug in ovarian cancer ... WebJan 1, 2024 · Regarding the frequency of ototoxicity of antineoplastic drugs and the dose required to trigger these effects, an important heterogeneity was observed. The frequency of ototoxicity caused by cisplatin ranged from 45% to 83.3% and, when used in combination with carboplatin, ranged from 16.6% to 75%.

WebEfficacy and safety of a cisplatin and paclitaxel (TP) induction regimen followed by chemoradiotherapy for patients with locally advanced head and neck squamous cell carcinoma (LAHNSCC)

WebPlatinum was measured in 46 serum samples from our blood collection pilot study. Three platinum isotopes were measured with consistent measurements across isotopes. Platinum levels ranged from 0.030 ug/L to 0.87ug/L at time points from 6-13 years after diagnosis with higher levels in cases who received chemotherapy (0.19ug/L vs 0.07ug/L, p=0.002). orchard flower homeowners association ipsen heat treatingWebThe dose-limiting side effect for cisplatin is nephrotoxicity, for carboplatin it is myelosuppression, and for oxaliplatin it is neurotoxicity. Other common side effects … orchard florist promo codeWebAlthough cisplatin has demonstrated its superiority over carboplatin for treatment of lung cancers and germ-cell tumors, the tolerance of carboplatin is better than that of … ipsen facebookWebCisplatin is used in the treatment of several childhood malignancies. Improvement in long -term survival has made the monitoring of long-term side effects more important. Nephrotoxicity and high frequency hearing loss are the most notable adverse effects of cisplatin in children. Brock et. al (1991) ipsen logistics tunisiaWebFinal results indicate that the investigational chemotherapeutic analogs CBDCA (JM-8) and CHIP (JM-9) do not produce the ototoxicity and nephrotoxicity characteristic of cisplatin. Furthermore, these findings demonstrate 195mpt localization in the vestibular labyrinth and confirm previous platinum distribution studies in the organ of Corti and ... ipsen jobs wrexhamWebSep 15, 2024 · Carboplatin (kar" boe pla' tin) is a cisplatin analog with a carboxy-cyclobutane moiety instead of the chloride atoms which makes it more stable and perhaps less toxic than cisplatin. Carboplatin and cisplatin act as alkylating agents causing cross linking between and within DNA strands, leading to inhibition of DNA, RNA and protein … ipsen market access