Fstl1 monocyte
WebResults FSTL1 expression was significantly elevated in macrophages from fibrotic livers of both humans and mice. Myeloid-specific FSTL1 deficiency effectively attenuated the … WebJan 28, 2014 · Follistatin-like protein 1 (FSTL-1) is a secreted gp produced mainly by cells of the mesenchymal lineage, such as cardiomyocytes, chondrocytes, fibroblasts, and endotheliocytes 1 - 6. It is not produced by cells of the hematopoietic lineage 2. FSTL-1 was initially cloned from a mouse osteoblast cell line as a TGF-β-inducible gene 7.
Fstl1 monocyte
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WebFSTL1 reduces transcellular transport of LDL-sized particles and of LDL itself, and inhibits endothelial activation. ... (NF-κB), adhesion molecule expression and monocyte … WebWhile cells of mesenchymal lineage are capable of FSTL1 production, FSTL1 expression is notably absent from cells of hematopoietic lineage under normal physiological conditions. Macrophages and monocytes are, however, capable of taking up FSTL1 at sites of inflammation where FSTL1 stimulation can cause the expression of caspase-1 and its ...
WebJun 1, 2024 · Furthermore, FSTL1 is an acidic cysteine-rich secreted protein and a member of the SPARC family based on protein domain similarity [5]. Indeed, FSTL1 binds to disco-interacting protein2 homolog A (DIP2A), which is a receptor for FSTL1 as evidenced by molecular interaction analyses by Ouchi et al. [6]. WebJan 2, 2024 · FSTL1 CD14 TLR4 Innate immunity Rheumatoid arthritis abstract Follistatin-related protein (FRP)/follistatin-like 1 (FSTL1) has multi-specific binding nature espe …
WebFSTL1, derived from fibroblasts/myofibroblasts in the interstitial compartment of the kidney can signal to kidney tubule cells in a paracrine manner, and contribute directly to the three cardinal processes that contribute to the progression of CKD: fibrosis, inflammation, and … WebFSTL1. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC.
WebSep 1, 2016 · Conversely, knockdown of FSTL1 significantly reduces the production of IL-6 and monocyte chemotactic protein 1 (MCP-1) induced by TNF-α and IL-17 [24]. Thus, these studies demonstrate that FSTL1 is a pro-inflammatory mediator that might be a target in treating inflammatory diseases, specifically rheumatoid arthritis.
WebOct 17, 2011 · The monocyte cell line U937, which does not express FSTL1, was transfected with a plasmid encoding FSTL1 and stimulated with phorbol myristate acetate and lipopolysaccharide. Cell supernatants were assayed for IL-6, IL-8, monocyte chemotactic protein 1 (MCP-1), and FSTL1 by enzyme-linked immunosorbent assay. the salon calabasasWebMar 21, 2024 · FSTL1 is a potential mediator of inflammation and insulin resistance in obesity. These results suggest that FSTL-1 may act on the NLRP3 inflammasome to … tradinglynWebFeb 8, 2024 · Myeloid- specific FSTL1- knock out (FSTL1 M- OK) mice were constructed to explore the function and mechanism of macrophage FSTL1 in 3 murine models of liver fibrosis induced by carbon tetrachloride injection, bile duct ligation or a methionine-deficient and choline-deficient diet. Results FSTL1 expression was significantly elevated the salon c4WebMay 17, 2014 · Follistatin-like protein 1 (FSTL1), a secreted glycoprotein, also named TSC-36 [transforming growth factor (TGF)β 1-stimulated clone 36] or FRP (follistatin-related protein), was originally cloned from the mouse osteoblastic cell line MC3T3-E1 [].FSTL1 is widely expressed in human and mouse tissues, although its expression was found to be … trading m1 financeWebFollistatin like-1 (FSTL1) is a secreted glycoprotein involved in a series of physiological and pathological processes. However, its contribution to the development of cancer, especially the pathogenesis of NSCLC, remains to be elucidated. We explored the expression, function, and molecular mechanis … trading lvl req gpoWebFeb 8, 2024 · demonstrated by attenuated infiltration of monocytes/ macrophages and neutrophils and decreased expression of proinflammatory factors. FSTL1M- OK … trading lowWebJun 1, 2024 · 1. Introduction. Follistatin-like protein 1 (FSTL1) is a glycoprotein first discovered by Prof. Shibanuma from the transforming growth factor (TGF) β-stimulated … the salon california carmel valley