Homeostatic chondrocytes
WebOur study demonstrates an important physiological role for CXCR1/2 signalling in maintaining cartilage homeostasis and suggests that the loss of ELR+ CXC … WebCOL11A1), homeostatic chondrocytes (HomCs, expres-sing TXNIP, IFITM3, GDF15 and TIMP1) and cartilage progenitor cells 2 (CPCs-2, expressing KIAA0101, BIRC5, CDKN3 and TMMN1) (Fig. 1C, D). Single-cell trajectory of normal chondrocyte differentiation To study the differentiation of healthy human chon-
Homeostatic chondrocytes
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Web27 jun. 2024 · Homeostatic chondrocytes mainly involved in functions of ossification, collagen fibril organization, and collagen binding etc.; while regulatory chondrocytes … WebThe C1 cluster was substantially composed of the OA cartilage with ProCs and prehypertrophic chondrocytes (preHTCs) as predicted cell subtype. Of significance, the overwhelming majority of C2 and C3 clusters were composed of the SIFK cartilage, C2 mainly contains the predicted homeostatic chondrocytes (HomCs), preHTCs and HTCs.
WebAutophagy deficiency has been related to OA pathogenesis because of the accumulation of cellular defects in chondrocytes. Microribonucleic acids (microRNAs or miRs) are a well-established class of posttranscriptional modulators belonging to the family of noncoding RNAs that have been identified as key players in the regulation of cellular processes, … Web14 jul. 2024 · Chondrocytes undergoing aging at multiple levels including genetic/epigenetic aberration, disruption in biochemical and bioenergetics related cellular …
Web27 mei 2024 · Chondrocytes are the key target cells of the cartilage degeneration that occurs in Kashin–Beck disease (KBD) and osteoarthritis (OA). Web17 jan. 2024 · gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes Commun Biol . 2024 …
WebAutophagy is a central housekeeping system that plays an antiaging role by supporting the clearance of senescence-associated alterations of macromolecules and organelles. …
Web15 nov. 2024 · In this study, scRNA-seq was used to identify potential markers for chondrocytes in osteoarthritis (OA) and to explore the function of different types … dr john walsh cardiologistWeb27 mei 2024 · The homeostatic and mitochondrial chondrocyte populations, which were identified by the expression of the unknown markers MT1X and MT2A and MT-ND1 and MT-ATP6, were markedly expanded in KBD. The regulatory chondrocyte population, identified by the expression of CHI3L1, was markedly expanded in OA. cognitive behavioral therapy austinWebHomeostatic chondrocytes ( Figure 7F) mainly involved in functions of ossification, collagen fibril organization, and collagen binding etc.; while regulatory chondrocytes ( Figure 7G) were... cognitive behavioral therapy basic conceptsWeb30 apr. 2024 · The mitochondrial permeability transition pore (mPTP) is a non-selective pore in the inner mitochondrial membrane (IMM) which causes depolarization when it opens under conditions of oxidative stress and high concentrations of Ca2+. In this study, a stochastic computational model was developed to better understand the dynamics of … cognitive behavioral therapy baton rougeWebThe chondrocyte subclusters were classified based on their potential regulatory, homeostatic, and effector functions in extracellular matrix (ECM) homeostasis. cognitive behavioral therapy behavior chainWeb17 jan. 2024 · Chondrocytes enter a phase of rapid division as they leave the resting zone of the growth plate, forming characteristic columns of mitotic cells that begin to secrete increased levels of... cognitive behavioral therapy bellevueWebHomeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis Curr Rheumatol Rep. 2013 Nov;15 (11):375. ... Chondrocytes produce cytokines, chemokines, alarmins, prostanoids, and adipokines and express numerous cell surface receptors for cytokines and chemokines, as well as Toll-like receptors. cognitive behavioral therapy and weight loss